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Properties of substance:

erythromycin



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C37H67NO13

Molar/atomic mass: 733.927

Melting point (°C):

196.3

CAS №: 114-07-8

Solubility (g/100 g of solvent):

1,2-dichloroethane: soluble [Ref.]
acetone: very soluble [Ref.]
acetonitrile: very soluble [Ref.]
amyl acetate: soluble [Ref.]
chloroform: very soluble [Ref.]
diethyl ether: soluble [Ref.]
ethanol: 20 (20°C) [Ref.]
ethyl acetate: very soluble [Ref.]
methanol: very soluble [Ref.]
water: 0.12 (30°C) [Ref.]
water: 0.04 (80°C) [Ref.]

Hygroscopic:

yes

Numerical data:

Year of discovery: 1952

Dissociation:

pKBH+ (1) = 8.8 (25°C, water)

LD50 (mg/kg):

4600 (rats, oral)
2580 (mice, oral)
426 (mice, intravenous)

References:

  1. Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1345-1346
  2. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 588-589
  3. Journal of Thermal Analysis and Calorimetry. - 2013. - Vol. 111, No. 2. - pp. 1025-1031 [DOI: 10.1007/s10973-012-2284-8]
  4. Journal of the American Chemical Society. - 1954. - Vol. 76, No. 12. - pp. 3121-3131 [DOI: 10.1021/ja01641a005]
  5. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 769-770
  6. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 537 [Russian]
  7. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 644-646 [Russian]
  8. Краткая химическая энциклопедия. - Т. 1: А-Е. - М.: Советская энциклопедия, 1961. - pp. 239-240 [Russian]
  9. Краткая химическая энциклопедия. - Т. 5: Т-Я. - М.: Советская энциклопедия, 1967. - pp. 1019-1020 [Russian]
  10. Халецкий А.М. Фармацевтическая химия. - Л.: Медицина, 1966. - pp. 710-715 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru