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Properties of substance:

quinine



skc-file

Group of substances:

organic

Physical appearance:

colorless crystals

Empirical formula (Hill's system for organic substances):

C20H24N2O2

Molar/atomic mass: 324.42

Melting point (°C):

174.9

CAS №: 130-95-0

Solubility (g/100 g of solvent):

acetone: 2.94 (15°C) [Ref.]
aniline: 14.4 (20°C) [Ref.]
benzene: 0.5 (20°C) [Ref.]
carbon tetrachloride: 0.53 (20°C) [Ref.]
chloroform: 52.6 (20°C) [Ref.]
diethyl ether: 6.2 (20°C) [Ref.]
diethylamine: 57 (20°C) [Ref.]
ethanol: 115 (20°C) [Ref.]
ethyl acetate: 24.7 (20°C) [Ref.]
glycerol: 0.633 (25°C) [Ref.]
glycerol 98.5%: 0.96 (20°C) [Ref.]
methanol: 168.7 (25°C) [Ref.]
piperidine: 118.8 (20°C) [Ref.]
pyridine: 100.8 (20°C) [Ref.]
quinoline: 22.2 (20°C) [Ref.]
water: 0.051 (15°C) [Ref.]
water: 0.05711 (25°C) [Ref.]
water: 0.13 (100°C) [Ref.]

Numerical data:

Year of discovery: 1820

Dissociation:

pKBH+ (1) = 8.52 (25°C, water)
pKBH+ (2) = 4.13 (25°C, water)

LD50 (mg/kg):

68 (mice, intravenous)

References:

  1. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 954
  2. Dictionary of organic compounds. - Vol. 3, naphthacarbazole - zygadenine. - М.: ИИЛ, 1949. - pp. 575
  3. Fattorusso E., Taglialatela-Scafati O. Modern Alkaloids. - Wiley-VCH Verlag, 2008.. - pp. 60
  4. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1775-1776
  5. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 797
  6. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 1157
  7. Муравьева Д.А. Тропические и субтропические лекарственные растения. - М.: Медицина, 1983. - pp. 179-183 [Russian]
  8. Новый справочник химика и технолога. Основные свойства неорганических, органических и элементоорганических соединений. - СПб.: НПО Профессионал, 2007. - pp. 1067 [Russian]
  9. Орехов А.П. Химия алкалоидов. - М.: ИАН СССР, 1955. - pp. 213 [Russian]
  10. Свойства органических соединений: Справочник. - Под ред. Потехина А.А. - Л.: Химия, 1984. - pp. 394-395 [Russian]
  11. Справочник по растворимости. - Т.1, Кн.2. - М.-Л.: ИАН СССР, 1962. - pp. 1151, 1249, 1283, 1306-1307, 1329, 1357, 1372, 1376, 1462, 1526, 1586 [Russian]
  12. Справочник химика. - Т. 2. - Л.-М.: Химия, 1964. - pp. 1076-1077 [Russian]
  13. Химическая энциклопедия. - Т. 5. - М.: Советская энциклопедия, 1999. - pp. 265-266 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru