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Properties of substance:

4-aminobenzoic acid

Group of substances:

organic

Physical appearance:

colorless crystals

Empirical formula (Hill's system for organic substances):

C7H7NO2

Structural formula as text:

H2NC6H4COOH

Molar/atomic mass: 137.136

Melting point (°C):

187

Solubility (g/100 g of solvent):

1,4-dioxane: 11.71 (25°C) [Ref.]
1-butanol: 6 (25°C) [Ref.]
acetic acid: soluble [Ref.]
benzene: 0.07 (25°C) [Ref.]
benzene: 0.35 (30°C) [Ref.]
benzylamine: sparingly soluble [Ref.]
dibutylamine: insoluble [Ref.]
diethyl ether: 2 (20°C) [Ref.]
diethylamine: insoluble [Ref.]
dipropylamine: insoluble [Ref.]
ethanol: 12 (20°C) [Ref.]
ethyl acetate: soluble [Ref.]
n-butylamine: sparingly soluble [Ref.]
tributylamine: insoluble [Ref.]
triethylamine: insoluble [Ref.]
water: 0.495 (18°C) [Ref.]
water: 0.5 (25°C) [Ref.]
water: 0.611 (30°C) [Ref.]
water: 0.84 (37°C) [Ref.]

Dissociation:

pKa (1) = 4.85 (25°C, water)

LD50 (mg/kg):

1830 (rabbits, oral)
2850 (mice, oral)
1000 (dogs, oral)

References:

  1. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 340-341
  2. Journal of Physical and Chemical Reference Data. - 2013. - Vol. 42, No. 3. - pp. 033103-115 - 033103-138
  3. Jouyban A. Handbook of solubility data for pharmaceutacals. – CRC Press, 2010. - pp. 72-73
  4. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 11ed. - Wiley-interscience, 2004. - pp. 152
  5. Seidell A. Solubilities of organic compounds. - 3ed., vol.2. - New York: D. Van Nostrand Company, 1941. - pp. 541
  6. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 385
  7. Справочник по растворимости. - Т.1, Кн.1. - М.-Л.: ИАН СССР, 1961. - pp. 476 [Russian]
  8. Справочник по растворимости. - Т.1, Кн.2. - М.-Л.: ИАН СССР, 1962. - pp. 1421 [Russian]
  9. Справочник химика. - Т. 2. - Л.-М.: Химия, 1964. - pp. 490-491 [Russian]
  10. Справочник химика. - Т. 3. - М.-Л.: Химия, 1965. - pp. 85 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru