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Properties of substance:

sendoxan



skc-file

Synonyms:

procytox
cyclophosphamide

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C7H17Cl2N2O3P

Molar/atomic mass: 279.1

Melting point (°C):

50

Solubility (g/100 g of solvent):

1,4-dioxane: soluble [Ref.]
acetone: difficulty soluble [Ref.]
benzene: soluble [Ref.]
chloroform: soluble [Ref.]
diethyl ether: difficulty soluble [Ref.]
ethanol: soluble [Ref.]
water: 2 (20°C) [Ref.]

LD50 (mg/kg):

130 (rabbits, intravenous)
200 (rats, intraperitoneal)
158 (mice, oral)
100 (mice, intraperitoneal)
40 (dogs, intravenous)

References:

  1. Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1182-1183
  2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 563
  3. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 148 [Russian]
  4. Проценко Л.Д., Булкина З.П. Химия и фармакология синтетических противоопухолевых препаратов. - Киев: Наукова думка, 1985. - pp. 63-75 [Russian]
  5. Химическая энциклопедия. - Т. 5. - М.: Советская энциклопедия, 1999. - pp. 377 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru