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Properties of substance:

digitoxin



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C41H64O13

Molar/atomic mass: 764.94

Melting point (°C):

256

CAS №: 71-63-6

Solubility (g/100 g of solvent):

chloroform: 2.5 (20°C) [Ref.]
diethyl ether: very slightly soluble [Ref.]
ethanol: 1.7 (20°C) [Ref.]
ethyl acetate: 0.25 (20°C) [Ref.]
methanol: sparingly soluble [Ref.]
petroleum ether: sparingly soluble [Ref.]
water: 0.001 (20°C) [Ref.]

LD50 (mg/kg):

0.18 (cats, oral)
0.17 (cats, intraperitoneal)
8.9 (, intravenous)
15.4 (, intravenous)
1.8 (guinea pig, intraperitoneal)
3.9 (mice, intraperitoneal)
0.286 (mens, oral)

References:

  1. Biological Reference Data on CD(SD)IGS Rats - 2002/2003. - 2002-2003. - pp. 3
  2. Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 1249-1251
  3. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 541-542
  4. Gangolli S. The Dictionary of Substances and their Effects. - 2 ed., Vol. 3, D. - RSC, 1999. - pp. 474-475
  5. Rocnik. - 2008. - LXXVII, №4. - pp. 162
  6. Yalkowsky S.H., Yan H., Jain P. Handbook of aqueous solubility data. – 2nd ed. - CRC Press, 2010. - pp. 1346
  7. Беликов В.Г. Учебное пособие по фармацевтической химии. - М.: Медицина, 1979. - pp. 417 [Russian]
  8. Полюдек-Фабини Р., Бейрих Т. Органический анализ. - Л.: Химия, 1981. - pp. 442-443 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru