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Properties of substance:

2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one



skc-file

Synonyms:

acyclovir
virolex

Group of substances:

organic

Physical appearance:

crystals

Empirical formula (Hill's system for organic substances):

C8H11N5O3

Molar/atomic mass: 225.20464

Melting point (°C):

256.5-257

CAS №: 59277-89-3

Solubility (g/100 g of solvent):

chloroform: practically insoluble [Ref.]
dimethylsulfoxide: very soluble [Ref.]
ethanol 96%: very slightly soluble [Ref.]
water: 0.14 (21°C) [Ref.]

LD50 (mg/kg):

910 (rats, intravenous)
620 (rats, subcutaneous)
860 (rats, intraperitoneal)
1118 (mice, intravenous)
1000 (mice, intraperitoneal)

References:

  1. ACS Omega. - 2017. - Vol. 2, No. 7. - pp. 3483-3493 [DOI: 10.1021/acsomega.7b00554]
  2. Elks J., Ganellin C.R. Dictionary of Drugs: Chemical Data, Structures and Bibliographies. - Springer, 1990. - pp. 13
  3. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 31-33
  4. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 11ed. - Wiley-interscience, 2004. - pp. 76
  5. Milne G.W.A. Gardner's Commercially Important Chemicals. - Wiley-Interscience, 2005. - pp. 13
  6. The Merck Index 11th ed., Merck & Company, 1989. - pp. 24
  7. Вартанян Р.С. Синтез основных лекарственных средств. - М.: МИА, 2004. - pp. 757-759 [Russian]
  8. Государственная Фармакопея Российской Федерации. - 12 изд., ч. 1 - М.: НЦЭСМП, 2008. - pp. 513-516 [Russian]
  9. Машковский М.Д. Лекарственные средства. - 13-е изд., Т. 2. - Харьков: Торсинг, 1997. - pp. 357 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru