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Properties of substance:
l-adrenaline
skc-file
Synonyms:
l-epinephrine
Group of substances:
organic
Empirical formula (Hill's system for organic substances):
C
9
H
1
3
NO
3
Molar/atomic mass: 183.204
Melting point (°C):
212
CAS №: 51-43-4
Solubility (g/100 g of solvent):
acetone
: insoluble [
Ref.
]
benzene
: insoluble [
Ref.
]
chloroform
: insoluble [
Ref.
]
diethyl ether
: insoluble [
Ref.
]
ethanol
: insoluble [
Ref.
]
water
: 0.018 (20°C) [
Ref.
]
water
: very soluble (100°C) [
Ref.
]
Reactions:
Yeild 85,5%. [
Ref.1
]
(HO)
2
C
6
H
3
CH(OH)CH
2
NHCH
3
+ 2NaHSO
3
→ (HO)
2
C
6
H
3
CH(SO
3
H)CH
2
NHCH
3
+ Na
2
SO
3
+ H
2
O
[
Ref.1
]
(HO)
2
C
6
H
3
CH(OH)CH
2
NHCH
3
→ (HO)
2
C
6
H
3
COCH
3
+ CH
3
NH
2
Dissociation:
pK
a
(1) = 8.66 (25°C, water)
pK
a
(2) = 9.95 (25°C, water)
LD
50
(mg/kg):
0.15 (rats, intravenous)
0.217 (mice, intravenous)
4 (mice, intraperitoneal)
0.1 (dogs, intravenous)
Spectral properties of the substance:
Ultraviolet/visible spectrum (maximum in nm, layer thickness 1 cm, in parentheses - extinction) = 280 (15)
References:
Clarke's Analysis of Drugs and Poisons. - 4 ed. - London, 2011. - pp. 832-833
Kleemann A. Pharmaceutical Substances. - 2000. - pp. 752-753
Mills T. III, Roberson J.C. Instrumental data for drug analysis. - 2 ed., Vol. 2. - 1993. - pp. 818-819
The Merck Index. - 15th ed. - Royal Society of Chemistry, 2013. - pp. 668
Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 597
Полюдек-Фабини Р., Бейрих Т. Органический анализ. - Л.: Химия, 1981. - pp. 275-276 [Russian]
Справочник химика. - 2 изд., Т. 2. - Л.-М.: Химия, 1964. - pp. 398-399 [Russian]
Химическая энциклопедия. - Т. 1. - М.: Советская энциклопедия, 1988. - pp. 36 [Russian]
Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советская энциклопедия, 1983. - pp. 11-12 [Russian]
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© Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru
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