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Properties of substance:

3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

Synonyms:

pentoxifylline
oxpentifylline

Group of substances:

organic

Physical appearance:

colorless needles crystals

Empirical formula (Hill's system for organic substances):

C13H18N4O3

Melting point (°C):

105

Solubility (g/100 g of solvent):

benzene: 12.5 [Ref.]
chloroform: very soluble [Ref.]
diethyl ether: sparingly soluble [Ref.]
ethanol: sparingly soluble [Ref.]
methanol: very soluble [Ref.]
water: 7.7 (25°C) [Ref.]
water: 19.1 (37°C) [Ref.]

Dissociation:

pKBH+ (1) = 0.3 (25°C, water)

LD50 (mg/kg):

1170 (rats, oral)
231 (rats, intravenous)
1225 (mice, oral)
108 (mice, intravenous)

References:

  1. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 838
  2. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1591-1593
  3. The Merck Index 11th ed., Merck & Company, 1989. - pp. 1131
  4. Граник В.Г. Основы медицинской химии. - М.: Вузовская книга, 2001. - pp. 327 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru