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Properties of substance:

indomethacin



skc-file

Group of substances:

organic

Physical appearance:

white crystals

Empirical formula (Hill's system for organic substances):

C19H16ClNO4

Molar/atomic mass: 357.79

Melting point (°C):

56

CAS №: 53-86-1

Solubility (g/100 g of solvent):

acetone: soluble [Ref.]
chloroform: sparingly soluble [Ref.]
ethanol: sparingly soluble [Ref.]
water: 0.00085 (25°C) [Ref.]

Dissociation:

pKa (1) = 4.5 (25°C, water)

LD50 (mg/kg):

15 (, oral)
20 (, oral)
13.8 (, intraperitoneal)
33 (mice, )
892 (mice, )
25.6 (, oral)

References:

  1. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1073-1075
  2. Yalkowsky S.H., Yan H. Handbook of aqueous solubility data. - CRC Press, 2003. - pp. 1124
  3. Токсикологическая химия. - Под ред. Плетеневой Т.В. - М.: ГЭОТАР-Медиа, 2005. - pp. 36 [Russian]
  4. Токсикологический вестник. - 2004. - №2. - pp. 38 [Russian]
  5. Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советская энциклопедия, 1983. - pp. 222 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru