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Properties of substance:

2,6-diisopropylphenol

Synonyms:

diprivan
propofol

Group of substances:

organic

Physical appearance:

colorless liquid

Empirical formula (Hill's system for organic substances):

C12H18O

Structural formula as text:

((CH3)2CH)2C6H3OH

Molar/atomic mass: 178.2707

Melting point (°C):

19

Boiling point (°C):

256

CAS ¹: 2078-54-8

Solubility (g/100 g of solvent):

2-propanol: sparingly soluble [Ref.]
cyclohexane: sparingly soluble [Ref.]
ethanol: very soluble [Ref.]
methanol: very soluble [Ref.]
water: 0.016 [Ref.]

Density:

0.955 (20°C, g/cm3)

Reactions of synthesis:

  1. Yeild 65%. [Ref.1aster]
    C6H5OH + 2CH3CH=CH2 → ((CH3)2CH)2C6H3OH
  2. Yeild 61%. [Ref.1]
    C6H5OH + 2CH3CH=CH2 → ((CH3)2CH)2C6H3OH
  3. Yeild 60%. [Ref.1aster, Ref.2aster, Ref.3aster]
    HO((CH3)2CH)2C6H2COOH + 2NaOH → ((CH3)2CH)2C6H3OH + Na2CO3 + H2O

Refractive index (nD):

1.514 (20°C)

Vapour pressure (Torr):

30 (136°C)

LD50 (mg/kg):

42 (rats, intravenous)
50 (mice, intravenous)
170 (mice, intraperitoneal)

References:

  1. Messina L.C., Silva de Espindola C., Omori A.T. Direct One-Pot Synthesis of Propofol from Paracetamol Tablets / ACS Sustainable Chemistry & Engineering. - 2023. - Vol. 11, No. 5. - pp. 1638-1642 [DOI: 10.1021/acssuschemeng.2c07483]
  2. CRC Handbook of Chemistry and Physics. - 90ed. - CRC Press, 2010. - pp. 3-442
  3. CRC Handbook of Chemistry and Physics. - 95ed. - CRC Press, 2014. - pp. 3-468
  4. Drugs. - 1987. - Vol. 34, No. 1. - pp. 115-119
  5. Elks J., Ganellin C.R. Dictionary of Drugs: Chemical Data, Structures and Bibliographies. - Springer, 1990. - pp. 425
  6. Lewis R.J. Sax's Dangerous Properties of Industrial Materials. - 12ed., Vol. 1-5. - Wiley, 2012. - pp. 1648
  7. Organic Process Research and Development. - 2014. - Vol. 18, No. 1. - pp. 152-156 [DOI: 10.1021/op400300t]
  8. The Merck Index. - 15th ed. - Royal Society of Chemistry, 2013. - pp. 1451-1452

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru