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Properties of substance:

piperazine



skc-file

Group of substances:

organic

Physical appearance:

colorless rhombic crystals

Empirical formula (Hill's system for organic substances):

C4H10N2

Structural formula as text:

HN(CH2CH2)2NH

Molar/atomic mass: 86.136

Melting point (°C):

104

Boiling point (°C):

145

CAS №: 110-85-0

Solubility (g/100 g of solvent):

diethyl ether: insoluble [Ref.]
ethanol 95%: 63.3 [Ref.]
glycerol: very soluble [Ref.]
water: soluble [Ref.]

Hygroscopic:

yes

Dissociation:

pKBH+ (1) = 9.81 (25°C, water)
pKBH+ (2) = 5.57 (25°C, water)

Standard molar enthalpy (heat) of formation ΔfH0 (298.15 K, kJ/mol):

-45.6 (s)

LD50 (mg/kg):

1900 (rats, oral)
1340 (rats, intravenous)
600 (mice, oral)
1180 (mice, intravenous)

References:

  1. Armarego W. L. F. Purification of Laboratory Chemicals. - 5ed. - 2003. - pp. 336
  2. CRC Handbook of Chemistry and Physics. - 90ed. - CRC Press, 2010. - pp. 5-27
  3. Clarke's isolation and identification of drugs. - 2ed. - London: Pharmaceutical press, 1986. - pp. 906-907
  4. Kleemann A. Pharmaceutical Substances. - 2000. - pp. 1651
  5. Stahl P.H., Wermuth C.G. Handbook of Pharmaceutical Salts: Properties, Selection, and Use. - Wiley-VCH, 2002. - pp. 321
  6. Гетероциклические соединения. - Т. 6, под ред. Эльдерфилда Р. - М.: ИИЛ, 1960. - pp. 344-350 [Russian]
  7. Краткая химическая энциклопедия. - Т. 3: Мальтаза-Пиролиз. - М.: Советская энциклопедия, 1964. - pp. 1041-1042 [Russian]
  8. Полюдек-Фабини Р., Бейрих Т. Органический анализ. - Л.: Химия, 1981. - pp. 309-310 [Russian]
  9. Справочник химика. - Т. 2. - Л.-М.: Химия, 1964. - pp. 878-879 [Russian]
  10. Справочник химика. - Т. 3. - М.-Л.: Химия, 1965. - pp. 103 [Russian]
  11. Химическая энциклопедия. - Т. 3. - М.: Советская энциклопедия, 1992. - pp. 519 [Russian]
  12. Химический энциклопедический словарь. - Под ред. Кнунянц И.Л. - М.: Советская энциклопедия, 1983. - pp. 439 [Russian]

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    © Collected Ruslan Anatolievich Kiper, burewestnik@mail.ru